Prep macaroni, pan and oven: Cook macaroni according to package directions. Drain and rinse under cold water to stop the cooking process (they will get mushy otherwise). Pour into a lightly greased 9x13" pan and set aside. Preheat your oven to 350 degrees F.
Make the roux: Melt the butter in a wide skillet. Whisk in the flour and cook, whisking constantly, until the flour is no longer foamy (about one minute).
Make the sauce: Carefully whisk in the milk and chicken broth (the pan is hot so watch out for splatters) and cook over medium heat, whisking constantly, until thickened (about 5-6 minutes). Take off the heat.
Finish the sauce and combine with macaroni: Stir in the mustard, salt and spices. Add the mozzarella and cheddar cheese. Stir well. Fold in the Greek yogurt. Combine with the macaroni in the pan.
Add breadcrumbs: Evenly sprinkle the breadcrumbs over the macaroni.
Bake and broil: Bake at 350 degrees for 15 minutes or until the sauce bubbles up on the sides. Brown the top under the broiler for 1 minute if you like.