Prep: Line a rimmed sheet pan with aluminum foil and lightly grease it (you can skip the foil, it just makes clean up a little messier). Preheat the oven to 350°F.
Make the meatloaf mix: Place all ingredients for the meatloaf in a large mixing bowl and combine well (I like using a hand mixer with the dough hook attachment for minimal mess and maximum convenience).
Shape: Shape meat mix into a loaf on the prepared pan. Create a deep crease down the middle and fill with mozzarella cheese. Tightly pinch the meat mix together on top of the cheese to close.
Bake: Spread entire loaf with 1/3 of the sauce. Bake for 30 minutes. Carefully spread with another 1/3 of the sauce and finish baking for 20-30 minutes, or until internal temperature of the meat reaches 160°F.
Finish: Remove cooked meatloaf from the oven. Immediately spread with remaining sauce. Allow to rest for 10 minutes before slicing.